REVIEW: MECHANISTIC INSIGHTS INTO THE EFFECT OF T HYROID DISORDERS ON ESTROGEN LEVEL AND BONE MINERAL DENSITY
By: Joshi, Minakshi
.
Contributor(s): Bisht, Shradha.
Publisher: M P Innovare Academic Sciences Pvt Ltd 2019Edition: Vol.11(10).Description: 9-17p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
International journal of pharmacy and pharmaceutical scienceSummary: Thyroid hormone serves as an indispensable componen
t for the optimum functioning of various biological
systems. They curb body’s metabolism,
regulates the estrogen level, regulates bone turnov
er, essential for skeletal development and minerali
zation. Within the scope of knowledge, it is
intimately familiar that thyroid disorders have wid
espread systemic manifestations, among which in hyp
othyroidism, even though elevated TSH
(thyroid-stimulating hormone) may reduce estrogen l
evel which in turn stimulates osteoclasts and thus
cause osteoporosis, while hyperthyroidism
accelerates bone turnover. Hypothyroidism does not d
irectly interfere with the skeletal integrity, but
treatment with levothyroxine for the
suppression of TSH to bring the hypothyroid patient
to euthyroid state for a long haul; lead to simulta
neous reduction in bone mass and in (bone
mineral density) BMD.
After the initial relevation of the correlation bet
ween thyroid disorders and osteoporosis in numerous
studies have emphasized that both hypo and
hyperthyroidism either directly or indirectly affec
ts the bone mineral density or leads to the progres
sion of osteoporosis.
Therefore the present study is aimed and so designe
d to review all the possible associations between t
hem and the impact of thyroid disorders on
estrogen level and bone mineral density.
The main findings of this review indicate that both
excesses as well as deficiency of thyroid hormone
can be potentially deleterious for bone tissue.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
|
School of Pharmacy Archieval Section | Not for loan | 2020858 |
Thyroid hormone serves as an indispensable componen
t for the optimum functioning of various biological
systems. They curb body’s metabolism,
regulates the estrogen level, regulates bone turnov
er, essential for skeletal development and minerali
zation. Within the scope of knowledge, it is
intimately familiar that thyroid disorders have wid
espread systemic manifestations, among which in hyp
othyroidism, even though elevated TSH
(thyroid-stimulating hormone) may reduce estrogen l
evel which in turn stimulates osteoclasts and thus
cause osteoporosis, while hyperthyroidism
accelerates bone turnover. Hypothyroidism does not d
irectly interfere with the skeletal integrity, but
treatment with levothyroxine for the
suppression of TSH to bring the hypothyroid patient
to euthyroid state for a long haul; lead to simulta
neous reduction in bone mass and in (bone
mineral density) BMD.
After the initial relevation of the correlation bet
ween thyroid disorders and osteoporosis in numerous
studies have emphasized that both hypo and
hyperthyroidism either directly or indirectly affec
ts the bone mineral density or leads to the progres
sion of osteoporosis.
Therefore the present study is aimed and so designe
d to review all the possible associations between t
hem and the impact of thyroid disorders on
estrogen level and bone mineral density.
The main findings of this review indicate that both
excesses as well as deficiency of thyroid hormone
can be potentially deleterious for bone tissue.
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